| San Francisco 49ers | @ | Cleveland Browns | |
| Standing | 17 | : | 19 |
| Purdy | Walker | |||
| | | 12 - 27 / 125 yds / 1 TD / 1 INT / 55,3 Rating | | | 18 - 34 / 192 yds / 0 TD / 2 INT/ 45,2 Rating |
| McCaffrey | J. Ford | |||
| | | 11 Att / 43 yds / 0 TD | | | 17 Att / 84 yds / 0 TD |
| Aiyuk | Cooper | |||
| | | 4 Rec, 10 Tgt/ 76 yds / 0 TD | | | 4 Rec, 8 Tgt / 108 yds / 0 TD |
| Moody | Hopkins | |||
| | | 1-3 FG / 2-2 PAT / 25y long | | | 4-5 FG / 1-1 PAT / 50y long |
| Hufanga | McLeod | |||
| | | 5 Tac / 2 Ass / 0 FF / 0 Sac | | | 7 Tac / 1 Ass / 0 FF / 0 Sac |
| Niners | Browns | |||
| Time of possession | | | 26 : 57 | | | 33 : 03 |
| Total Yards/Plays/Drives | | | 215 / 55 / 13 | | | 334 / 70 / 13 |
| Passing/Att/1stdowns | | | 107 yds / 12-27 / 5 | | | 174 yds / 18-34 / 6 |
| Rushing/Att/1stdowns | | | 108 yds / 25 / 6 | | | 160 yds / 34 / 10 |
| First Downs/by penalty | | | 15 / 4 | | | 18 / 2 |
| Third Downs | | | 3 – 12 / 25 % | | | 3 – 13 / 23 % |
| Fourth Downs | | | 0 - 0 | | | 1 - 1 |
| Red Zone/TD | | | 2 – 3 / 67 % | | | 1 – 2 / 50 % |
| Ave Yds per play | | | 3,9 | | | 4,8 |
| Ave Yds per Rush/Pass | | | 4,3 / 3,6 | | | 4,7 / 4,8 |
| Penalties-Yards | | | 12 – 105 | | | 13 - 119 |
| Sacked- Yards Lost | | | 3 - 18 | | | 2 - 18 |
| Fumbles/Lost | | | 1 / 0 | | | 1 / 0 |
| Interceptions Thrown | | | 1 | | | 2 |
| Punts/In20/TB | | | 6 / 2 / 0 | | | 4 / 3 / 1 |
| Ave Punt/Long | | | 52,3 / 60,0 | | | 54,5 / 69,0 |