| San Francisco 49ers | @ | Jacksonville Jaguars | |
| Standing | 34 | : | 3 |
| Box score | 10 / 3 / 14 / 7 | | | 0 / 3 / 0 / 0 |
| Purdy | Lawrence | |||
| | | 19 - 26 / 296 yds / 3 TD / 0 INT / 148,9 Rating | | | 17 - 29 / 185 yds / 0 TD / 2 INT/ 48,8 Rating |
| McCaffrey | Etienne Jr. | |||
| | | 16 Att / 95 yds / 0 TD | | | 9 Att / 35 yds / 0 TD |
| Kittle | Kirk | |||
| | | 3 Rec, 4 Tgt/ 116 yds / 1 TD | | | 6 Rec, 11 Tgt / 104 yds / 0 TD |
| Moody | McManus | |||
| | | 2-2 FG / 4-4 PAT / 39y long | | | 1-1 FG / 0-0 PAT / 37y long |
| Greenlaw | Lloyd | |||
| | | 6 Tac / 2 Ass / 0 FF / 0 Sac | | | 7 Tac / 3 Ass / 0 FF / 0 Sac |
| Niners | Jaguars | |||
| Time of possession | | | 33 : 11 | | | 26 : 49 |
| Total Yards/Plays/Drives | | | 437 / 60 / 11 | | | 221 / 54 / 10 |
| Passing/Att/1stdowns | | | 293 yds / 20-28 / 11 | | | 162 yds / 18-32 / 7 |
| Rushing/Att/1stdowns | | | 144 yds / 30 / 8 | | | 59 yds / 17 / 2 |
| First Downs/by penalty | | | 20 / 1 | | | 12 / 3 |
| Third Downs | | | 4 – 12 / 33 % | | | 4 – 12 / 33 % |
| Fourth Downs | | | 1 - 2 | | | 0 - 1 |
| Red Zone/TD | | | 1 – 4 / 25 % | | | 0 – 1 / 0 % |
| Ave Yds per play | | | 7,3 | | | 4,1 |
| Ave Yds per Rush/Pass | | | 4,8 / 9,8 | | | 3,5 / 4,4 |
| Penalties-Yards | | | 7 – 90 | | | 5 - 39 |
| Sacked- Yards Lost | | | 2 - 9 | | | 5 - 28 |
| Fumbles/Lost | | | 0 / 0 | | | 2 / 2 |
| Interceptions Thrown | | | 0 | | | 2 |
| Punts/In20/TB | | | 3 / 2 / 0 | | | 5 / 0 / 1 |
| Ave Punt/Long | | | 47,0 / 56,0 | | | 53,6 / 62,0 |